Yu Gu

prof_pic.jpg

顾禹 (Gù Yǔ) — Aiden

I’m a researcher and entrepreneur focused on turning foundational AI models into real-world solutions across science, technology, and industry. Now at Microsoft Research and Microsoft Health & LIfe Science, I previously co-founded a Series C AI startup, scaling foundational research into enterprise-grade solutions.

My work centers on large-scale foundation models , multimodal learning , robotics and agentic AI frameworks , with real-world deployments across healthcare, life sciences, and beyond.

Selected Highlights

  • PubMedBERT : Pioneered one of the first domain-adaptive language models in biomedicine ( ACM HLTH Best Paper ), with 20M+ downloads , 2000+ citations , and integration into Azure Text Analytics for Health, serving 10+ major institutions.
  • BiomedParse : Created a best-in-class universal segmentation model ( Nature Methods ), delivering state-of-the-art performance across CT, MRI, and pathology. 1M+ monthlydownloads ; #1 in CVPR 2025 3D Biomedical Segmentation Challenge .
  • BiomedJourney : Developed a generative model for counterfactual image generation, enabling robust interpretation of disease progression and deployment in data-scarce settings.
  • Multi-Agent Systems : Built agentic LLM frameworks for collaborative clinical reasoning, showcased at the World Economic Forum and Microsoft Build , improving tumor board decision-making in complex oncology cases.
  • Startup : Co-founded and scaled an AI healthcare company to enterprise adoption, culminating in a Series C acquisition .

Published in Nature , Cell , ICLR , ACL , and more. Reviewer for Nature journals, TMI, NeurIPS , etc. Work featured by Forbes, CNBC, and the World Economic Forum .

news

Jun 05, 2025 BiomedParse topped the CVPR 2025 3D Biomedical Image Segmentation Challenge! Our model delivered best-in-class performance across 42 tasks spanning CT, MRI, PET, ultrasound, and microscopy. check out: announcement
May 28, 2025 At Microsoft Build, we introduced the Healthcare Agent Orchestrator, now available in Azure AI Foundry Agent Catalog. For details: HAO science blog
Apr 01, 2025 Our recent publication in Nature Communications: “𝘼 𝙘𝙡𝙞𝙣𝙞𝙘𝙖𝙡𝙡𝙮 𝙖𝙘𝙘𝙚𝙨𝙨𝙞𝙗𝙡𝙚 𝙨𝙢𝙖𝙡𝙡 𝙢𝙪𝙡𝙩𝙞𝙢𝙤𝙙𝙖𝙡 𝙧𝙖𝙙𝙞𝙤𝙡𝙤𝙜𝙮 𝙢𝙤𝙙𝙚𝙡 𝙖𝙣𝙙 𝙚𝙫𝙖𝙡𝙪𝙖𝙩𝙞𝙤𝙣 𝙢𝙚𝙩𝙧𝙞𝙘 𝙛𝙤𝙧 𝙘𝙝𝙚𝙨𝙩 𝙓-𝙧𝙖𝙮 𝙛𝙞𝙣𝙙𝙞𝙣𝙜𝙨
Mar 05, 2025 3D segmentation made simple - #MedImageParse 3D is live! #MedImageParse is now optimized for 3D imaging. Check out the blog by David Ardman: https://www.microsoft.com/en-us/industry/blog/healthcare/2025/03/03/leading-the-charge-to-transform-healthcare-with-advanced-ai/
Feb 20, 2025 We’re excited to unveil Magma—our flagship multimodal AI project (Multimodal Agentic Model at Microsoft ReseArch). Today, we released Magma on arXiv (2502.13130), along with its Project Page and GitHub repo. The project has already captured significant community attention, with top influencers sharing the news.

selected publications

  1. x-reasoner.png
    X-reasoner: Towards generalizable reasoning across modalities and domains
    Qianchu Liu, Sheng Zhang, Guanghui Qin, and 8 more authors
    arXiv preprint arXiv:2505.03981, 2025
  2. magma.png
    Magma: A Foundation Model for Multimodal AI Agents
    Jianwei Yang, Reuben Tan, Qianhui Wu, and 10 more authors
    2025
  3. pubmedbert.png
    Domain-specific language model pretraining for biomedical natural language processing
    Yu Gu, Robert Tinn, Hao Cheng, and 6 more authors
    ACM, 2022
  4. universalner.svg
    Universalner: Targeted distillation from large language models for open named entity recognition
    Wenxuan Zhou, Sheng Zhang, Yu Gu, and 2 more authors
    In ICLR, 2024
  5. biomedjourney.png
    Biomedjourney: Counterfactual biomedical image generation by instruction-learning from multimodal patient journeys
    Yu Gu, Jianwei Yang, Naoto Usuyama, and 5 more authors
    arXiv preprint arXiv:2310.10765, 2024
  6. gigapath.webp
    A whole-slide foundation model for digital pathology from real-world data
    Hanwen Xu, Naoto Usuyama, Jaspreet Bagga, and 8 more authors
    Nature, 2024
  7. biomedparse.png
    A foundation model for joint segmentation, detection and recognition of biomedical objects across nine modalities
    Theodore* Zhao, Yu* Gu, Jianwei Yang, and 8 more authors
    Nature methods, 2024